Laser-Induced Thermal Therapy in the Management of Low-Grade Gliomas: A Narrative Review
DOI:
https://doi.org/10.52609/jmlph.v5i2.177Keywords:
Blood-Brain Barrier, Glioma, Laser TherapyAbstract
Background:
Low-grade gliomas (LGGs) are slow-growing, World Health Organization Grade I and II tumors that can transform into more aggres-sive malignancies over time. This transformation pre- sents significant challenges in managing the burden of health care. Laser-induced thermal therapy (LITT) has emerged as a promising minimally invasive treat-ment option for LGGs, offering precise tumor ablation with minimal damage to surrounding tissues.
Method:
This narrative review synthesizes data from relevant studies on the evolution, clinical manifestations, mo-lecular characteristics, and emerging management strategies for LGGs, with a focus on the role of LITT.
Results:
LITT, a minimally invasive technique, offers targeted tumor ablation with the added benefit of disrupting the blood-brain barrier to enhance drug delivery. Studies have shown that LITT can effectively reduce tumor size and improve survival rates in patients with both primary and recurrent gliomas. However, challenges such as procedure-related complications, including motor deficits and cerebral edema, as well as the need for further research on long-term efficacy, remain.
Conclusion:
LITT represents a significant advancement in the treatment of LGGs, combining precision and minimal invasiveness. Future studies should focus on optimiz-ing protocols, integrating molecular and genetic in-sights, and assessing long-term outcomes to enhance therapeutic efficacy and patient quality of life.
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Copyright (c) 2025 Ibrahim Omar Dalabeh, Hossam Salameh, Yasmin Dahabreh, Abdallah Ali Al-Zayadneh, Mehreen Amir, Ayman Haitham Khaled, Malak A. Hassan, Azad Jehad Makableh, Mohammad Omar Dalabeh
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